PA was associated with a higher incidence of hyperparathyroidism, higher level of iPTH, lower level of vitamin D, hypercalciuria, and a higher incidence of osteopenia/osteoporosis compared to patients with essential hypertension (25, 26) and can be reversed by mineralocorticoid receptor antagonists (e.g. spironolactone) or adrenalectomy (27). This evidence concerns the gene NR3C2 and osteoporosis.