Analysis of the production of double-stranded RNA (dsRNA) intermediates, a marker of viral replication complex assembly/genome replication intermediate, showed that at 48 h p.i., there is a massive increase in dsRNA-containing complexes in NPM1-KD cells compared to in NPM1 control cells after infection (Fig. 1n and o; Fig. S1c). Here, NPM1 is linked to infection.