Therefore, EEs could inhibit cytopigments P450 (CYP450) to reduce the production of T. Phthalates increase the production of testicular testosterone in foetal rats (low‐dose effect), but high dose will reduce the production of testicular testosterone in foetal rats, resulting in a lower incidence of anogenital distance and increased incidence of cryptorchidism.47 The gene discussed is CYP2B6; the disease is cryptorchidism.