We found that umbelliprenin treatment did not change the protein expression level of β‐catenin, Shh, and SUFU (Figure 7A), indicating that Wnt/β‐catenin and Hedgehog signaling pathways are not involved in the umbelliprenin‐mediated inhibition of pancreatic cancer cell stemness. Here, SUFU is linked to pancreatic neoplasm.