FH and cardiovascular disorder: By contrast, and again as noted previously,20,22 the prevalence and incidence of cardiovascular disease was lower in those of African origin, although this effect was largely explained by sociodemographic, lifestyle, environmental, and clinical factors.20 However, overall, as more efforts are needed to improve FH diagnosis, our findings suggest that FH-variant carriers in all 3 ancestry groups have similar mean LDL-C concentration and that the commonly used FH diagnostic threshold of LDL-C>4.9 mmol/L might perform similarly at detecting affected FH individuals.