Previous studies reported that TAM could influence cancer metastasis and formation of blood or lymphatic vessels.[12, 42, 43] TNF‐α has been shown to increase lymphatic vessel permeability by modulating the cytoskeleton of endothelial cells.[44] Here, we posit that TAM recruitment caused by CRIP1 overexpression promote LM by increasing the permeability of lymphatic vessels via secreting TNF‐α, which may enrich the understanding of TAM in promoting LM formation. This evidence concerns the gene TNF and cancer.