The lymphangiogenesis together with increased lymphatic permeability facilitated tumor cell intravasation into lymph vessels and promoted metastatic dissemination in lymph nodes.[39, 40, 41] In our study, we found that CRIP1 not only promoted lymphangiogenesis in GC, but also increased the lymphatic permeability of the lymph vessels. The gene discussed is CRIP1; the disease is neoplasm.