Additionally, YAP inhibitor (Verteporfin [Ver], 2.5 μm) and eIF4F inhibitors (4EGI‐1, 2.5 μm and SAN, 2 μm) significantly reduced the size and YAP expression of Apcmin/+EcsitcKO tumor organoids (Figure 5H,I and Figure S16E,F, Supporting Information) illustrating for the role of the eIF4F‐YAP axis in driving the pro‐tumorigenic phenotype resulting from ECSIT deficiency. Here, EIF4E is linked to neoplasm.