Moreover, eIF4F complex in the Eif pathway is the downstream target of mTOR signaling[16] and can selectively promote the translation initiation of specific mRNAs and trigger cancer development.[16b] Notably, our scRNA‐seq and IF data both showed that eIF4F members, particularly eIF4A1and eIF4G2, were significantly upregulated in cKO stem “‐like” cells compared with control cells (Figure 3F–H and Figure S9F, Supporting Information). This evidence concerns the gene EIF4G1 and cancer.