Moreover, YAP is critical in inducing stem cell proliferation during the regeneration phase of intestinal injury,[3, 4, 26] and YAP induces the expression of many progenitor‐specific genes.[27] YAP expression and activation must be tightly controlled and transient, otherwise it will result in an inability to reacquire homeostasis upon tissue damage, thereby resulting in the development of cancer.[22, 28] Here we reveal a critical mechanism underlying intestinal tumorigenesis that is driven by ECSIT loss to enhance the levels of translation of YAP protein in an eIF4F‐mediated manner. The gene discussed is ECSIT; the disease is cancer.