MMP2 and neoplasm: Compared with other groups, mHAase + MMP‐2 had the highest uptake in HepG2 cells, further indicating that mHAase + MMP‐2 damaged the ECM and played an important role in enhancing drug uptake in tumor cells (Figure 10G).[92] HAase cannot be expressed through gene modification in nonnucleated cells such as red blood cells; therefore, to modify HAase on the surface of red blood cells, chemical modification can be adopted.