Studies have shown that POM121 inhibits macrophage inflammatory response by reducing NF-κB phosphorylated P65 nucleation, which is associated with tumor lymph node metastasis staging (Zhang et al., 2020), and the expression of USP34 in diffuse large B-cell lymphoma is significantly higher than that in reactive lymphoid hyperplasia (Li et al., 2018). The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.