reported that the frequency of both slow‐metabolizing ADH1B and inactive ALDH2 (double inactivated group) was 19.1% and that metachronous esophageal SCC (p < 0.001) and metachronous head and neck SCC (p = 0.001) were more common in the double‐inactivated group.18 The gene discussed is ALDH2; the disease is esophageal squamous cell carcinoma.