Recently, researchers have constructed a prognostic model using endoplasmic reticulum (ER) stress-related genes (ERSRGs), including PON1, AGR2, SSR2, and TMCC1, which could accurately predict the survival outcomes of patients with HCC and also be associated with malignant degree, recurrence rate, late TNM stage, late T stage, and hepatitis B virus (HBV) infection (29). The gene discussed is SSR2; the disease is hepatocellular carcinoma.