CXCL1 and familial pancreatic carcinoma: It has also been found that senescent PSCs boost the migration and proliferation of MIAPaCa-2 cell lines and pancreatic carcinoma AsPC-1 via the CXCL1/CXCR2 axis, where CXCL1, CXCL2 and CXCL3 are senescence-related secretory phenotypic elements secreted from the senescence-induced PSCs, and CXCL1/CXCR2 axis antagonists attenuate their migration and proliferation of pancreatic cancer cell stimulatory effects.