CD8A and cancer: In a mouse model, it was discovered that the activated PSCs regulate chemokines, cytokines, and T cell adhesion molecules for migration, reduce the CD8 T cell migration to peritumoral tumor stromal compartments, thereby impeding their entry into cancer cells, and blocking antitumor immune responses (29).IL-6 and STAT3 secreted in the supernatant of PSCs boost the differentiation of peripheral blood mononuclear cells (PBMC) into myeloid-derived suppressor cells (MDSC) and inhibit autologous T cell proliferation.