It was also found that peptidylarginine deiminase 4 (PADI4) deficiency transplanted into Kras-driven pancreatic adenocarcinoma (Pdx1-Cre : Kras) mice -/- G12D/+, DNA released from Neutrophil extracellular trap activated PSCs, formed a dense fibrous stroma, and promoted tumor growth. Here, KRAS is linked to pancreatic adenocarcinoma.