In addition, we show that autophagy promotes proline biosynthesis through mitophagy-mediated regulation of NADK 2 (mitochondrial NAD kinase 2), an enzyme responsible for mitochondrial NADP (H) production, Targeting PRKN (parkin RBR E3 ubiquitin protein ligase) in the matrix to inhibit cellular mitophagy reduced tumor weight. The gene discussed is PRKN; the disease is neoplasm.