RNF43 and colorectal carcinoma: To further verify the prognostic influence of RNF43 mutation in BRAF mutant CRC patients, we collected a total of 358 BRAF mutant CRC samples from 6 cohorts in cBioPortal (coad_cptac_2019, coadread_tcga_pan_can_atlas_2018, coadread_tcga_pub, coadread_tcga, crc_apc_impact_2020 and crc_msk_2017), including 116 samples with RNF43 mutation and 242 samples with RNF43 wild-type (Supplementary Tables 3, 4).