A previously healthy 16-year-old girl, lacking a known family history of MEN1, presented with progressive weight gain, hirsutism, acne, irregular menses, extensive skin striae, fatigue, and muscle weakness associated with a cortisol-producing adrenal adenoma, leading to identification of a frameshift mutation in MEN1 in the proband and multiple family members (41). Here, MEN1 is linked to acne.