While threshold values of 260 pg/mL and 270 pg/mL were proposed in differentiating patients with Insulin Resistance and MetS, respectively (32), in our sample mean values of circulating FGF-21 in diabetics and metabolic patients were lower and in line to another study that found median FGF-21 concentration of 239.9 pg/mL in diabetics subjects (33). The gene discussed is FGF21; the disease is Insulin resistance.