In conclusions, our newly calculated cut-off of total FGF-21 according to visceral adiposity identified subjects with fasting hyperglycemia, and visceral adiposity appears to be responsible for increased levels of total FGF-21, although this does not necessarily translate into an increased hormonal biological activity, since levels of intact functional FGF-21 hormone are not related to abdominal obesity. The gene discussed is FGF21; the disease is Abdominal obesity.