PDGFA and myocardial infarction: Recently published research in preclinical models of myocardial infarction has shown that treatment with recombinant PDGF-AB protein (Asli et al., 2019; Thavapalachandran et al., 2020) and overexpression of the Pdgf-a gene via recombinant adeno-associated virus mediated gene transfer (Rashid et al., 2021) improves cardiac function after myocardial infarction via fibroblast and macrophage activation and enhanced angiogenesis in the infarct border zone, leading to improved scar alignment and mechanics.