Further supporting this, a following study of the same group showed that a tumour-reactive CD8+ T cell clone, also specific to the same immunodominant peptide mentioned above, was able to cross-recognise numerous peptides and that stimulation of this clone with these peptides drove the expansion of a heterogeneous CD8+ T cell population, with only a fraction actually reacting to the Melan-A peptide (117). Here, CD8A is linked to neoplasm.