Altogether, the strong anti-gluten CD4+ T cell response present in CeD is providing help to B cells that bind TG2-gliadin complexes and deaminated gluten peptides to mature into plasma cells in the gut that in turn produce deaminated gluten-specific, as well as autoreactive, TG2-specific, Abs (60–62). This evidence concerns the gene TGM2 and cranioectodermal dysplasia.