In conclusion, the present study showed prometastatic effects of desipramine and fluoxetine, but not mirtazapine, by modulating secondary liver colonization during colon carcinoma progression, and that these effects are associated with the effects of antidepressants on cytokines, i.e., enhanced IL-10 and reduced IL-1 β and IFN-γ levels. The gene discussed is IL10; the disease is colon carcinoma.