CD274 and cancer: It suggested a significant impact of antidepressants on the expression of PD-1 and/or PDL-1 on cells of the immune system and cancer cells (increased expression of PD-1 on cells eliminating cancer cells and, at the same time, increased expression of PD-L1 on cancer cells, induced by some antidepressants, may be an important cause of the progression of the neoplastic process).