Figures 2A, B, 3A, B show that the levels of both serum and spleen IFN-γ and IL-1β were decreased after desipramine- and fluoxetine- but not those of mirtazapine in C26 cc cells-bearing mice after 14 days of treatment. Particularly drastic was the decrease in spleen IFN-γ levels in desipramine-treated tumor-bearing mice (up to 96%, Figure 3A). Desipramine significantly increased (214%) serum IL-10 levels (Figure 2C), whilst desipramine and fluoxetine increased the levels of this cytokine produced by the splenocytes collected from tumor-bearing mice (Figure 3C). This evidence concerns the gene IFNG and neoplasm.