Furthermore, in chronic hepatitis C virus infection, it has been shown that a PD-1+CD127+TCF1+ progenitor subset with elevated levels of CD127 was maintained after removal of antigen stimulation and generated more exhausted PD-1hiCD127-TCF1- CD8 T cells upon antigenic stimulation (44, 45). The gene discussed is IL7R; the disease is chronic hepatitis C virus infection.