Autoantibodies play a crucial role not only in the development of MS but also in other autoimmune disorders in CNS, such as myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder, anti-N-methyl-D-aspartate receptor encephalitis, and systemic lupus with neuropsychiatric manifestations (9). The gene discussed is MOG; the disease is autoimmune disease.