Induction of ATP7A has been shown to cause renal fibrosis (30).MiRNA-1297 inhibits myocardial fibrosis by downregulating ULK1 (31),and short-chain fatty acids attenuate renal fibrosis via the HDAC2/ULK1 axis in metallotranscription factor-1 (MTF-1) has been shown to promote fibrosis (32). This evidence concerns the gene HDAC2 and Myocardial fibrosis.