MTF1, ULK1, ATP7A are associated with multiple inflammatory factors such as IL5, TNF, IL7, IL15, TGFB2, PDGFA, CSF3, CSF1, CD4, IL6, HLA-DRB1, HLA-DRA, etc., thus we found the excellent potential value of cuproptosis in the immunotherapy of HS. This evidence concerns the gene HLA-DRA and histiocytic sarcoma.