In this study, we investigated the gene expression profiles of PBMCs and CD8+ T cells after infection with PRRSV strain AUT15-33 over 21 days by identifying the differentially expressed genes and conducting time-course clustering analysis at four time points (0, 7, 14 and 21 dpi) to determine gene expression dynamics of the immune response against PRRSV. Here, CD8A is linked to infection.