Table 1 summarizes clinical, surgical and prognostic variables for all patients included. 6 patients had missing data concerning the type of surgical operation that lead to GBM diagnosis and, among these, 5 had missing data regarding MGMT promoter methylation status, thus were not considered for survival analyses that included clinical-prognostic factors as regressors. The frequency maps of the distribution of the core and the edema are shown in Figure 1. The gene discussed is MGMT; the disease is glioblastoma.