KCNQ2 and Epileptic encephalopathy: We found that Kcnq2 deletion leads to increased GABAergic interneuron network excitability, suggesting that KCNQ2 loss-of-function pathogenic variants would alter not only excitatory neuronal excitability, but also GABAergic interneuron network excitability early in development, an effect that might contribute to the developmental and epileptic encephalopathy phenotype of KCNQ2 DEE patients.