CD8A and Autoimmunity: While this technology has yet to be widely utilized in autoimmunity, Kasmani et al. (2023) used this program to show that CD8+ TCR avidity correlates with an exhausted fate during persistent infection by lymphocytic choriomeningitis virus in mice, where TCR sequences were paired with the peptide KAVYNFATC and the mouse class I MHC H-2Db.