In another study, the antiproliferative and apoptosis-promoting effects of paeonol in ovarian cancer may be related to paeonol-induced cytoprotective autophagy, as evidenced by a significant increase in the expression of the autophagy marker LC3-II and a decrease in the expression of p62, accompanied by the accumulation of autophagosomes and autolysosomes, while inhibition of the Akt/mTOR pathway is paeonol-induced autophagy in ovarian cancer cells and induction of apoptosis key. The gene discussed is AKT1; the disease is ovarian carcinoma.