IGHE and allergic bronchopulmonary aspergillosis: CFTR-dependent altered regulation of T-cell cytokine secretion leads to a shift towards a proinflammatory state and a predominant Th2 response with exaggerated IgE levels, a predisposition for allergic bronchopulmonary aspergillosis (ABPA) and simultaneously reduced defense against Pseudomonas aeruginosa (Moss et al, 1996; Muller et al, 2006; Mueller et al, 2011; Ratner and Mueller, 2012; Duan et al, 2021).