A randomized, double-blind, placebo-controlled clinical trial supported the idea of saffron in treating diabetes, in which it was found that type II diabetes patients who took 100 mg/day of saffron powder for 8 weeks lowered the fasting blood glucose and TNF-α serum levels, along with downregulation of TNF-α and IL-6 mRNA expression (Mobasseri et al., 2020a). This evidence concerns the gene TNF and diabetes mellitus.