In a Japanese retrospective cross-sectional investigation, Miyake et al. (9) reported that ALT could be a useful indicator for the diagnosis of NAFLD; Vozarova et al. (18) observed that an increase in ALT level was associated with the degradation of insulin resistance and predicted the progression of T2D; Nakanishi et al. (38) found that GGT was a predictor for developing MS and T2D; Henley et al. (39) showed that ALT could predict the risk of MS in an epidemiological study. The gene discussed is GPT; the disease is Insulin resistance.