In our previous study, we found that serum myoglobin is associated with AKI, especially in patients with serum myoglobin exceeded 100 mg/dL.[11] Based on the clinical practice required, it is urgent to further study the dose-effects relationship and molecular mechanism of myoglobin and AKI, and possible preventive drugs for myoglobinemia caused by EHS and AKI. The gene discussed is MB; the disease is acute kidney injury.