p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of reactive oxygen species(ROS).[14,15] It is unclear whether myoglobin has an effect on ferroptosis in kidney tubular cells, i.e., the cells most affected in heatstroke complicated with AKI. Here, GPX4 is linked to acute kidney injury.