TP53 and neoplasm: Baicalein can also block arachidonic acid 12 lipoxygenase (ALOX12), which is necessary for p53 to mediate tumor inhibition through different ferroptosis pathways.[48,49] This experiment found that baicalein played a vital role in the process of myoglobin-mediated renal tubular injury after heat stress and effectively relieved myoglobin-mediated renal tubular injury by inhibiting ERS and ferroptosis.