It is known that if the serum myoglobin is more than 100 mg/dL, there will be tawny urine and apoptosis of renal tubular cells.[30] The concentration of myoglobin (1.5 mg/dL) is just the lowest value serving as the baseline of myoglobinuria (renal threshold), indicating that myoglobin concentration has different effects on renal tubular injury, emphasizing the possibility of ferroptosis in the early stage of AKI. This evidence concerns the gene MB and acute kidney injury.