ABCG2 and cancer: In contrast, the RuZ Autodock scores for ABCG2 and ABCB1 were -4.88 and -5.88 kcal/mol, respectively, indicating that RuZ has a significantly lower affinity for these transporters.[6] Therefore, it is unlikely that RuZ will be removed from the intracellular milieu of MDA-MB-231 cancer cells expressing the ABCG2 and ABCB1 transporters, i.e., there will not be a significant decrease in the levels of RuZ, thus, increasing the efficacy of RuZ.