As shown in Figure 7E–I, mRNAs expression of Bip, PERK, eIF‐2α, ATF4, and CHOP were all increased in the islet tissues of T2DM mice, and SENDs greatly reduced expression of these genes by 46.1%, 14.7%, 54.7%, 54.6%, 43.4% (5 mg kg−1). This evidence concerns the gene EIF2AK3 and type 2 diabetes mellitus.