Additionally, several cancer pathways were related to miR‐1248 (particularly ErbB and MAPK signalling) through these target genes: MYC, SP1, BRCA1, CCND2, CDKN1A, IL5, NOTCH2, PRKCB, etc. Thus, miRNA analyses together with pathway enrichment data showed that increased level of hsa_circ_0000228 might lead, through miR‐1248 binding, to deregulation of many key cellular processes, including proliferation, differentiation, apoptosis and stress response. The gene discussed is NOTCH2; the disease is cancer.