Many humoral factors, such as BMP2, TGFβ, IGF1, IGFBP3, PDGF, FGF, VEGF, WNT, ET1, PSA, uPA, and MDA‐BF‐1, released by PCa are known to play a role in osteogenesis [8]. Here, EDN1 is linked to posterior cortical atrophy.