In conclusion, in the present study, we have demonstrated that the transcription factor IFI30 can serve as an indicator of a poor prognosis in glioma and that IFI30 promotes the EMT‐like process of glioma cells by regulating the EGFR/AKT/GSK3β/β‐catenin signaling pathway, which subsequently enhances the invasion and chemoresistance of glioma cells. Here, IFI30 is linked to glioma.