Normally, cancer cells utilize iron through the cysteine desulfurase (NFS1)-iron-sulfur cluster assembly enzyme (ISCU)-CDGSH iron-sulfur domain-containing protein 1 and 2 (CISD1/2) axis to inhibit mitochondrial lipid peroxidation and ferroptosis; when Fe2+ in mitochondria is overloaded, it induces enzyme inactivation, impaired iron metabolism and ferroptosis [19–21 ]. Here, ISCU is linked to cancer.