A study by Chan H Han et al. on survivin promoter polymorphisms (-1547 A/G,-644C/T,-625C/G,-241C/T and -31G/C) and their association with the age of onset of ovarian cancer observed that -625C/G was persistently involved in ovarian cancer compared to other polymorphisms [48]. This evidence concerns the gene BIRC5 and ovarian carcinoma.