In addition, the inactivation of adr-1 and adr-2, encoded by Caenorhabditis elegans’ respective orthologs of ADARB1 and ADARB2, reduces lifespan [45], whereas mutations in ADAR or ADARB1 are associated with neurodevelopmental disorders, such as developmental epileptic encephalopathy and bilateral striatal necrosis [79,80,81]. This evidence concerns the gene ADARB1 and developmental and epileptic encephalopathy.