We further investigated the most significant over-represented pathway in our analysis, i.e., one of the well-documented MECP2 regulatory WikiPathways (WP4312) for Rett-syndrome-causing genes in Homo sapiens (adjusted p-value = 5.1 × 10−37), and identified a total of 3 RTT genes and 22 RTT-L genes, together representing the following pathway. The gene discussed is MECP2; the disease is Rett syndrome.