CYP27A1 and Wilson disease: Similarly, in an atherogenic mouse model with Cyp27a1 deficiency, Zurkinden et al. [92,93] reported that Cyp27a1/ApoE double-knockout mice were resistant to WD-induced liver inflammation, as demonstrated by their lowered hepatic inflammatory and oxidative stress gene expressions (i.e., Tnfα and Il1b).