In support of this assumption, reports on animal models of Parkinson’s disease [39] and autoimmune encephalomyelitis [45] argue that AQP4 is a modulator of neuroinflammation via regulating the release of inflammatory cytokines such as IL1b, IL6, TNFa and ATP from astrocytes which lead to activation of microglia. The gene discussed is TNF; the disease is Parkinson disease.