MTOR and neoplasm: Above all, FBXW7 is regarded as a strong p53-dependent tumor suppressor controlling human cell growth, cell cycle progression and tumor development through the direction of various oncoproteins such as Aurora A, cyclin E, c-Jun, c-Myb, c-Myc, JUNB, KLF5, Mcl1, MED13, mammalian target of rapamycin (mTOR), NF1, NFκB2, Notch, NRF1, p63, SREBP, NONO, and for ubiquitin-mediated proteolysis [18,19,20,21,22,23,24,25].