ARMS2 and obesity due to melanocortin 4 receptor deficiency: This multifactorial disease is caused by both environmental and genetic risk factors [23]: smoking; air pollution; ultraviolet radiation; metabolic diseases (e.g., obesity, hypertension, and diabetes); consumption of dietary fats [24,25,26,27]; and genetic polymorphisms such as cfh and arms2/hrta1 genes [28].