However, the CXCL1/CXCL8-CXCR2 axis may also cooperate with other chemokines in gastric cancer cell migration, particularly C-X-C motif ligand 12 (CXCL12, stromal-derived factor-1 (SDF-1))-CXCR4. The gene discussed is CXCR2; the disease is gastric cancer.