In particular, this refers to C-X-C motif ligand 5 (CXCL5, epithelial neutrophil-activating protein 78 (ENA78)) and CXCL8, which expression in pancreatic ductal adenocarcinoma tumors are the highest among CXCR2 ligands [166]. This evidence concerns the gene CXCR2 and pancreatic ductal adenocarcinoma.