This effect of CXCL1 on pancreatic cancer cells can be negated if they have a high expression of atypical chemokine receptor 1 (ACKR1, Duffy antigen receptor for chemokines (DARC)) [187], an atypical receptor for various chemokines including CXCL1 [188] which inhibits the activity of CXCR2 and thus the action of CXCL1. Here, CXCL1 is linked to familial pancreatic carcinoma.