Further, gastric cancer cells secrete extracellular vesicles that alter the expression of various genes in different cells in the tumor niche, for example extracellular vesicles that contain miR-155, miR-193b and miR-210, inducing the expression of chemokines CXCL1 and CXCL8 in fibroblasts [108]. Here, CXCL1 is linked to neoplasm.