A cross-sectional study was conducted to evaluate if the transcript levels of BCL2, BAX and TP53 are dysregulated in peripheral blood samples from total MJD subjects (Figure 2A) or in samples from subgroups of preclinical subjects, patients, and early patients, comparing with age- and sex-matched paired controls (Figure 2B,C). The gene discussed is TP53; the disease is Machado-Joseph disease.