In addition, similar blood abundance of BCL2 transcripts and the BCL2/BAX transcript ratio was found here in MJD preclinical subjects and matched controls (n = 19), also contrasting with previous reports showing reduced BCL2 levels [18] and the BCL2/BAX transcript ratio in the blood of preclinical subjects (n = 16) [8]. This evidence concerns the gene BAX and Machado-Joseph disease.