In both a polymicrobial model of sepsis induced by CLP (cecal ligation and perforation) [10] and endotoxemia induced by high LPS dose [9], the overexpression of GILZ in the macrophage lineage reduced systemic inflammatory cytokine levels and led to better survival, associated with reduced bacteremia and increased bacteria phagocytosis [9,10]. Here, TSC22D3 is linked to serum lipopolysaccharide activity.