It was reported that in an ovariectomized (OVX)-induced osteoporosis rat model, EPFs significantly increased the osteocalcin serum level and decreased tartrate-resistant acid phosphatase 5b (TRACP5b), which is an enzyme and a biomarker of bone-resorbing osteoclasts [110,113,114]. The gene discussed is ACP5; the disease is osteoporosis.