HCRT and Anxiety: Our laboratory recently demonstrated the functional importance of specific Hcrt subpopulations in mediating ethanol-induced behaviors [7], showing that ablation of the ectopic POA Hcrt neurons or the Hcrt neurons in the most anterior part of the aAH blocks the ethanol-induced increase in anxiety-like behavior, and ablation of the ectopic Hcrt neurons blocks the ethanol-induced increase in locomotor behavior.