TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is known to start a broad inflammatory response through the production of cytokines (interleukins, IL-1, IL-6, IL-8, and Tumor Necrosis Factor alpha, TNF-α), adipokines (leptin, adiponectin, resistin, and inhibitors of plasminogen activator-1), and other bioactive substances, such as Reactive Oxygen Species (ROS), by adipose tissue [6,7,8].