In addition to these proteins, other proteins related to the metabolic process were also reduced or absent in samples of stimulated saliva in the groups of pregnant women with obesity (OP and OWP), such as the following: Transketolase; Pyruvate kinase; Glucose-6-phosphate isomerase; Triosephosphate isomerase; L-lactate dehydrogenase A-like 6A; L-lactate dehydrogenase C chain; and Fatty acid-binding protein (Tables S1 and S2). The gene discussed is TKT; the disease is obesity due to melanocortin 4 receptor deficiency.